Key result
Thrombophilia and recurrent pregnancy loss research centers primarily on factor V Leiden and antiphospholipid syndrome.
Why the study?
The association between thrombophilia and recurrent pregnancy loss remains uncertain despite increasing research on thrombophilia.
Answers are grounded in this paper and cite their sources.
This bibliometric analysis maps the 30-year research landscape of thrombophilia and recurrent pregnancy loss, highlighting key focus areas in etiology, diagnostics, and therapeutics, and suggesting a growing need to study this relationship in in-vitro fertilization.
Background: Thrombophilia is a group of disorders that result in a blood hypercoagulable state and induce thrombosis, which was found widely existed in recurrent pregnancy loss (RPL). More and more research about thrombophilia has been conducted but the association between thrombophilia and RPL remains uncertain. Thus, it’s necessary to combine relevant literature to find the research hotspots and analyze the internal link between different study points, and then predict the development trend in RPL with thrombophilia.Methods: Relevant articles between 1990 and 2022 were obtained from the Web of Science (WoS) database. Software VOSviewer and CiteSpace were used to perform the analysis and conduct visualization of scientific productivity and emerging trends.Results: 742 articles published in recent 30 years by 3205 authors from 1139 organizations and 68 countries were analyzed. 37authors, 38 countries, and 53 organizations published papers ≥5. The USA was the most productive country and Univ Amsterdam was the most productive institution. Journal thrombosis and haemostasis had the most total citations. In keyword and clusters, factor-v-Leiden, inherited thrombophilia, activated protein-c, low-dose aspirin, molecular-weigh heparin, polymorphism had high-frequency focus on its etiology, diagnostics, and therapeutics. The strongest keyword bursts showed the research hotspots changed over time.Conclusions: By Bibliometric Analysis, we comprehensively reviewed publications related to thrombophilia and RPL during the past 30 years. The research in the relationship between thrombophilia and RPL suggested that there could be differences in the clinical relevance of the different types of thrombophilia. And we should attach more attention to this relationship in in-vitro fertilization.
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Deng et al. (2022) studied Thrombophilia and recurrent pregnancy loss (n=742). Bibliometric analysis was evaluated on Publication trends, productive countries/institutions, and keyword hotspots. Bibliometric analysis of 742 articles over 30 years revealed that research on thrombophilia and recurrent pregnancy loss focuses heavily on factor V Leiden, inherited thrombophilia, and antiphospholipid syndrome.
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