The Passerini Reaction with CF3‐Carbonyl Compounds – Multicomponent Approach to Trifluoromethyl Depsipeptides

The first detailed investigation of the Paserini reaction with CF3‐carbonyl compounds is reported. The reaction provides a new approach to trifluorolactic acid derivatives and CF3‐substituted depsipeptides. The method is promising for the synthesis of chiral trifluoromethyl depsipeptides, i.e. orthogonally protected building blocks for incorporation into naturally occurring depsipeptides.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)