Ruxolitinib, a potent JAK1/JAK2 inhibitor, induces temporary reductions in the allelic burden of concurrent CSF3R mutations in chronic neutrophilic leukemia

Chronic neutrophilic leukemia (CNL) is an uncommon BCR-ABL1 -negative myeloproliferative neoplasm (MPN). Its true incidence remains unknown with only ~200 cases described in literature, and it is most likely under-diagnosed. The disease course is often heterogeneous, ranging from a relatively