Key result
A 39-year-old female died 40 hours after an oral colchicine overdose, with a blood concentration of 250 microgram/L at 2 hours post-ingestion and no drug detected at death.
Case Report (n=1)
A fatal case of colchicine overdose demonstrated a blood concentration of 250 microgram/L at 2 hours post-ingestion, with no drug detectable at the time of death 40 hours later.
Colchicine overdose may cause delayed death despite undetectable levels at autopsy; this case report leaves open toxicokinetic thresholds for future series.
A colchicine blood concentration 250 microgram/L was determined in a 39-year-old white female 2 hours following the ingestion of an oral overdose of the drug. At death, 40 hours following ingestion, no drug was detected. Colchicine was extracted from buffered blood using dichloromethane. The evaporated extract was redissolved in 0.1 N HCl and analyzed using a high performance liquid chromatograph equipped with an octadecylsilane reversed phase column.
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Caplan et al. (1980) conducted a case report in Colchicine overdose (n=1). Colchicine overdose was evaluated on Death. A 39-year-old female died 40 hours after an oral colchicine overdose, with a blood concentration of 250 microgram/L at 2 hours post-ingestion and no drug detected at death.
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