Key result
SRC coregulators play a critical role in energy balance and adipogenesis.
Why the study?
The detailed mechanisms underlying fat pad expansion and the interrelationship of cellular and molecular events in adipocyte differentiation are not completely understood.
This review summarizes the role of coregulators, particularly the SRC (p160) coactivator family, in adipogenesis and energy balance.
Supports targeted research on cell cycle regulators in adipogenesis to address CV risk; leaves open clinical translation.
Strong epidemiological studies clearly show that reduction in body fat content decreases the risk for many clinical conditions including diabetes, hypertension, coronary atherosclerotic heart disease and some forms of cancer. Therefore, detailed understanding of the mechanisms underlying how fat pads expand appears crucial. Extensive studies already identified a cohort of transcription factors involved in adipocyte differentiation but the fine interrelationship between the myriads of cellular and molecular events occurring during this complex biological process is far from being completely understood. Since the cloning of the first coregulator, the impact of those molecules has dramatically increased. In this review, we will summarize the emerging impact of coregulators on energy balance with a specific interest for fat formation. Emphasis will be given to the coactivators of the SRC (p160) family.
No takes yet. Share an insight, caveat, or question.
Louet et al. (2007) conducted a review in Adipogenesis and energy balance. SRC (p160) coactivator family was evaluated. Coregulators, particularly the SRC (p160) coactivator family, play an emerging and crucial role in energy balance and fat formation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: