Secondary Amyloidosis in Lepromatous Leprosy

Article1 May 1965Secondary Amyloidosis in Lepromatous LeprosyPossible Relationships of Diet and EnvironmentRALPH C. WILLIAMS JR., M.D., EDGAR S. CATHCART, M.D., EVAN CALKINS, M.D., GEORGE L. FITE, M.D., JOSÉ BARBA RUBIO, M.D., ALAN S. COHEN, M.D.RALPH C. WILLIAMS JR., M.D.Search for more papers by this author, EDGAR S. CATHCART, M.D.Search for more papers by this author, EVAN CALKINS, M.D.Search for more papers by this author, GEORGE L. FITE, M.D.Search for more papers by this author, JOSÉ BARBA RUBIO, M.D.Search for more papers by this author, ALAN S. COHEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-1000 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptClinical and pathologic studies, conducted at the U. S. Public Health Service Hospital, Carville, La., indicate that amyloidosis is present in approximately one third of the patients with lepromatous leprosy currently at that institution (1, 2). Amyloid deposits have been found at autopsy in 50% of individuals who died during the course of lepromatous leprosy at Carville (3).The high incidence of amyloidosis in this country, however, is in striking contrast to the apparent incidence in lepromatous patients from other areas of the world such as India, Africa, Mexico, or Japan, where it is regarded as a rare complication of...References1. WOLCOTT RR: Erythema nodosum in leprosy. Int. J. Leprosy 15: 380, 1957. Google Scholar2. SHUTTLEWORTHROSS JSH: Secondary amyloidosis in leprosy. Ann. Intern. Med. 45: 23, 1956. LinkGoogle Scholar3. POWELLSWAN CSLL: Leprosy: pathological changes observed in fifty consecutive necropsies. Amer. J. Path. 31: 1, 131, 1955. MedlineGoogle Scholar4. 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LinkGoogle Scholar24. HELLERSOHARGAFNISHELLER HEJJ: Amyloidosis in familial Mediterranean fever. Arch. Intern. Med. (Chicago) 107: 539, 1961. CrossrefMedlineGoogle Scholar25. COHENGROSSSHIRAHAMA ASEST: Production of amyloid by tissue expiants. Arthritis Rheum. 7: 301, 1964. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RALPH C. WILLIAMSJR., M.D.; EDGAR S. CATHCART, M.D.; EVAN CALKINS, M.D.; GEORGE L. FITE, M.D.; JOSÉ BARBA RUBIO, M.D.; ALAN S. COHEN, M.D.Affiliations: Carville, Louisiana, and Guadalajara, Jalisco,From the U. S. Public Health Service Hospital, Carville, La., and the lnstituto Dermatologico, Guadalajara, Jalisco, Mexico.This study was supported by grants AM 04599, AM 05581-03-SI, AM 07372, and T1 AM 5285 and AM-05589 from the National Institute of Arthritis and Metabolic Disease, U. S. Public Health Service, Bethesda, Md.Requests for reprints should be addressed to Dr. Ralph C. Williams, Jr., M.D., Department of Medicine, University Hospital, Minneapolis, Minn. 55455. 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FUSARO, M.D., PH.D.Pathologie und Klinik der LepraAmyloidoseImmunologic Reactivity in Patients with LeprosyJOHN N. SHEAGREN, M.D., JEROME B. BLOCK, M.D., F.A.C.P., JOHN R. TRAUTMAN, M.D., SHELDON M. WOLFF, M.D., F.A.C.P.Case 23-1968Pulp death in a patient with lepromatous leprosyAmyloidosis 1 May 1965Volume 62, Issue 5Page: 1000-1007KeywordsAmyloidosisAutopsyErythemaLeprosyMalariaMedical servicesMetabolic disordersSyphilisTuberculosisUlcers ePublished: 1 December 2008 Issue Published: 1 May 1965 PDF downloadLoading ...