Key result
Exercise interventions may reduce kinesiophobia in CV patients but limited safety data and heterogeneity restrict conclusions.
Why the study?
The effectiveness and safety of exercise interventions for kinesiophobia in patients with cardiovascular disease were not well established.
Do exercise interventions reduce kinesiophobia in patients with cardiovascular disease?
Meta-Analysis
Do exercise interventions reduce kinesiophobia in patients with cardiovascular disease?
Current evidence is insufficient to make definitive recommendations regarding exercise interventions for kinesiophobia in cardiovascular patients due to small sample sizes, high heterogeneity, and limited safety data.
Exercise for kinesiophobia in CVD should not yet change practice; leaves open optimal protocols and safety in larger trials.
PURPOSE: To evaluate the effectiveness and safety of exercise interventions for kinesiophobia in patients with cardiovascular disease. METHODS: The system searched eight databases, covering periods from database creation to November 27, 2025. The RoB 2.0 and the ROBINS-I were used to assess the quality of the study. Meta-analysis was performed using Review Manager 5.4 software with random-effects models, supplemented by subgroup analyses and sensitivity analyses to explore sources of heterogeneity. RESULTS: = 93%), although all included studies were rated as having moderate risk of bias. Based on the limited available data (2 of 10 studies), the existing dataset is inadequate to form robust, generalizable judgments about the safety profile of exercise interventions for this population. Exploratory subgroup analyses detected numerical differences in pooled effect sizes across different exercise parameters, yet these observational trends cannot support definitive exercise recommendations due to small sample sizes. CONCLUSION: Exercise to reduced kinesiophobia in cardiovascular patients, limited safety records and substantial heterogeneity across moderate-quality evidence restrict definitive inferences. REPORTING METHODOLOGY: PRISMA 2020 statement. PROSPERO REGISTRATION NUMBER: CRD42025646414.
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Zheng et al. (2026) conducted a meta-analysis in cardiovascular disease with kinesiophobia. Exercise interventions was evaluated on kinesiophobia and safety. Exercise interventions may reduce kinesiophobia in cardiovascular patients, but limited safety records and substantial heterogeneity restrict definitive inferences.
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