Key result
Polygenic scores trained on Black/Black British individuals outperformed White-trained scores for a minority of traits, but explained less variance for the majority of traits.
Observational
Targeted collection of genetic data from underrepresented groups is necessary to address differences in polygenic score performance across ancestries, as statistical reweighting provides only modest benefits.
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L. W. Holmqvist (2001) conducted an observational in Fifteen traits. Polygenic scores trained on Black/Black British individuals vs. Polygenic scores trained on White individuals was evaluated on Predictive performance of polygenic scores. Polygenic scores trained on Black/Black British individuals outperformed White-trained scores for a minority of traits, but explained less variance for the majority of traits.
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