Differential scanning calorimetry was used as a screening technique for assessing the compatibility of nalidixic acid with some of the direct compression excipients. Nalidixic acid was found to be compatible with Brownex sugar, sorbitol, mannitol and granular mannitol, while incompatible with Cab-0-Sil, Di-Pac, Emdex and dicalcium phosphate dihydrate. It appears that stearic acid and L-(-)-leucine can be used as lubricants in formulations containing nalidixic acid while magnesium stearate cannot.
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Hamed H. El‐Shattawy (1984) studied this question.
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