Key result
C-kit+ cells show functionally negligible cardiomyocyte generation after neonatal cardiac injury, generating <0.0015% of cells.
Why the study?
Does neonatal cardiac apical resection induce C-kit+ cells to significantly contribute to de novo cardiomyogenesis in neonatal mice?
Does neonatal cardiac apical resection induce C-kit+ cells to significantly contribute to de novo cardiomyogenesis in neonatal mice?
Genetic fate-mapping demonstrates that endogenous cardiac C-kit+ cells are predominantly endothelial and do not significantly contribute to new cardiomyocyte formation during neonatal heart regeneration in mice.
Answers are grounded in this paper and cite their sources.
C-kit+ cells contribute negligibly to neonatal cardiomyogenesis after resection; leaves open alternative mechanisms and cautions against C-kit-targeted regenerative strategies.
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Elhelaly et al. (2019) studied Neonatal cardiac apical resection injury. Apical resection at postnatal day 2 with 4-OH tamoxifen C-kit lineage tracing vs. Age-matched sham-operated animals was evaluated on C-kit+ cell-derived cardiomyocytes (tdTomato+/Tnnt2+ cells per section at P21 in inducible model). C-kit+ cells accounted for <0.0015% of cardiomyocytes in inducible lineage-tracing mice after neonatal apical resection.
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