Key result
Maternal high-fat diet during lactation permanently impaired brown adipose tissue thermogenesis in offspring mice, leading to increased adiposity and metabolic dysfunction.
Why the study?
Does maternal high-fat diet during lactation impair thermogenic function of brown adipose tissue in offspring mice?
Population
Female mice and their offspring
Comparison
High-fat diet fed to mothers during lactation vs Control diet fed to mothers during lactation
Design
Preclinical
Follow-up
From weaning into adulthood
Authors
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Maternal HFD effects on offspring BAT remain hypothesis-generating in mice; extends preclinical serotonin data but should not change practice.
Does maternal high-fat diet during lactation impair thermogenic function of brown adipose tissue in offspring mice?
Maternal high-fat diet during lactation impairs brown adipose tissue thermogenesis in offspring via elevated peripheral serotonin, predisposing them to metabolic disorders.
Liang et al. (2016) studied Maternal high-fat diet induced metabolic dysfunction. Maternal high-fat diet vs. Control diet (10% energy from fat) was evaluated on Brown adipose tissue thermogenic function and adiposity. Maternal high-fat diet during lactation permanently impaired brown adipose tissue thermogenesis in offspring mice, leading to increased adiposity and metabolic dysfunction.
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