Key result
Small, dense LDL in hypertriglyceridemia is linked to a ~3-fold increase in CAD risk.
Why the study?
The independent predictive value of elevated triglycerides in coronary artery disease is difficult to establish due to diverse triglyceride-rich lipoprotein particles and associated low HDL cholesterol.
Population
Patients with hypertriglyceridemia at risk for coronary artery disease
Design
Review
Authors
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Complicates attributing CAD risk to triglycerides alone; leaves open whether specific particles confer independent atherogenicity.
Elevated triglycerides and the associated small, dense LDL phenotype play a primary role in atherosclerosis, suggesting that lipid-lowering strategies should target risk factors beyond LDL cholesterol.
Richard J. Rapp (2002) conducted a review in Hypertriglyceridemia and coronary artery disease. Hypertriglyceridemia and small, dense LDL phenotype was evaluated. The small, dense low-density lipoprotein phenotype in hypertriglyceridemia states is associated with a threefold increase in coronary artery disease risk.
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