Key result
Primary thyroid lymphoma had a 5-year survival rate of 70%, with an unfavorable prognosis linked to diffuse histology, large cell or immunoblastic type, and cervical lymph node involvement.
Observational (n=20)
Primary thyroid lymphomas are predominantly B-cell non-Hodgkin's lymphomas associated with chronic thyroiditis, with a 70% 5-year survival rate that worsens with diffuse histology and lymph node involvement.
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May inform prognosis discussions in rare primary thyroid lymphoma; leaves open prospective validation before guiding care.
Twenty cases of malignant lymphoma arising in the thyroid gland were studied clinically, histologically and immunohistochemically. Nineteen cases were non-Hodgkin's lymphoma (15 diffuse and four follicular lymphoma) and one was a plasmacytoma. Immunohistochemical analysis of the lymphomas using paraffin-embedded sections disclosed that 17 lymphomas were B-cell type and two were T-cell type. The plasmacytoma was of IgG kappa type. The large majority of the lymphomas were associated with an underlying chronic thyroiditis. The 5-year survival rate of the patients was 70%. An unfavourable diagnosis was more likely when the tumour was diffuse rather than follicular, when it was of diffuse large cell type or of immunoblastic type and when there was cervical lymph node involvement.
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Mizukami et al. (1990) conducted an observational in Primary lymphoma of the thyroid (n=20). Histological and immunohistochemical characteristics was evaluated on 5-year survival rate. Primary thyroid lymphoma had a 5-year survival rate of 70%, with an unfavorable prognosis linked to diffuse histology, large cell or immunoblastic type, and cervical lymph node involvement.
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