Key result
Salmeterol produced a significantly prolonged bronchodilator effect compared with salbutamol in normal subjects (mean AUC480 22,500 vs 14,100 kPa-1).
Why the study?
Does salmeterol improve specific airway conductance compared to salbutamol and placebo in normal subjects?
RCT (n=10)
Double-blind
randomised
Does salmeterol improve specific airway conductance compared to salbutamol and placebo in normal subjects?
Salmeterol produces a significantly prolonged bronchodilator effect compared with salbutamol in normal subjects.
Answers are grounded in this paper and cite their sources.
Comparable early effects in healthy subjects warrant caution before patient extrapolation; extends beta-agonist duration data but leaves clinical translation open.
The effects of salmeterol hydroxynaphthoate (50 micrograms, 8.3 x 10(-8) M) and salbutamol (200 micrograms, 3.5 x 10(-7) M) on sGaw were compared in a double-blind, placebo-controlled, randomised study in 10 normal subjects. 2. SGaw increased by 29% (14-43) (mean (CI)), 5 min after salmeterol and by 35% (19-51) at 15 min compared with an increase of 32% (14-51) and 37% (10-63) after salbutamol and 4% (-3-11) and 8% (0-16) after placebo. 3. The mean area under the sGaw-time curve (AUC480) after salmeterol inhalation was 22,500 kPa-1 (10,100-39,500) compared with 14100 kPa-1 (8020-24,500) after salbutamol and 5300 kPa-1 (1500-10,400) after placebo. 4. Salmeterol produced a significantly prolonged bronchodilator effect compared with salbutamol in normals.
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Spring et al. (1992) conducted an RCT in Normal subjects (n=10). Salmeterol hydroxynaphthoate vs. Salbutamol (200 micrograms) and placebo was evaluated on Mean area under the sGaw-time curve (AUC480). Salmeterol produced a significantly prolonged bronchodilator effect compared with salbutamol in normal subjects (mean AUC480 22,500 vs 14,100 kPa-1).
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