Key result
Analysis of hepatitis C virus quasispecies variants may reveal mechanisms of infection persistence and enable prediction of interferon efficacy by detecting resistant strains.
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Analysis of HCV quasispecies variants may help predict interferon efficacy and understand mechanisms of viral persistence and carcinogenesis.
It has been shown that hepatitis C virus (HCV) populations in infected individuals are composed of quasispecies with diverse mutations. The analysis of these variants may reveal mechanisms of the persistence of HCV infection, carcinogenesis and resistance to antiviral therapy. Recently, genetic features of interferon-resistant HCV have been elucidated through the analysis of interferon-resistant quasispecies, making it possible to predict interferon efficacy by detecting interferon-resistant strains.
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Enomoto et al. (1995) conducted a review in Hepatitis C virus (HCV) infection. Analysis of HCV quasispecies was evaluated. Analysis of hepatitis C virus quasispecies variants may reveal mechanisms of infection persistence and enable prediction of interferon efficacy by detecting resistant strains.
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