Key result
Transcript length acts as a key determinant of translation efficiency, where the proximity of the 3' end to the ribosomal recruitment site in shorter mRNAs induces a feedback mechanism that favors ribosome recycling.
Population
Theoretical physical model of mRNA translation considering kinetics of ribosomes advancing on mRNA and…
Design
Preclinical
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Transcript length may refine mRNA design for protein output; leaves open validation in cardiovascular translation models.
Transcript length may play a central role in establishing ribosome recruitment and the overall translation rate of an mRNA by favoring ribosome recycling.
A 2017 study studied this question. Transcript length was evaluated on Ribosome density and translation efficiency. Transcript length acts as a key determinant of translation efficiency, where the proximity of the 3' end to the ribosomal recruitment site in shorter mRNAs induces a feedback mechanism that favors ribosome recycling.
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