MRTFB regulates the expression of NOMO1 in colon

Kodama et al. (1) report the function of myocardin-related transcription factor B (MRTFB) in colorectal cancer (CRC). They perform whole transcriptome RNA sequencing in MRTFB small interference RNA knockdown primary human colon cells and find that spindle apparatus coiled-coil protein 1 (SPDL1) and melanoma cell adhesion molecule (MCAM) show different expression. Subsequently, they conduct gene knockout experiments to prove that the deletion of these two genes can aggravate CRC. Finally, they concluded that MRTFB suppresses CRC development by regulating SPDL1 and MCAM. We deeply agree with Kodama et al.'s views on … [↵][1]1To whom correspondence may be addressed. Email: tianyi.zang{at}hit.edu.cn or liangcheng{at}hrbmu.edu.cn. [1]: #xref-corresp-1-1