Key result
Adding waist circumference improves visceral adipose tissue estimation, but metabolomic markers add no predictive value.
Why the study?
Visceral adipose tissue is a strong prognostic factor for cardiovascular disease but is difficult to measure in clinical practice, motivating the evaluation of prediction models using routine clinical measurements.
Does the addition of waist circumference and metabolomics to routine clinical measurements improve the estimation of visceral adipose tissue?
Comparison
Routine clinical measurements alone vs addition of waist circumference, other anthropometrics, and lipoprotein-related metabolites
Design
Observational cohort study with external validation
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Waist circumference may enhance VAT estimation in clinical models; leaves open metabolomics utility in observational cohorts.
Observational (n=4,772)
Yes
Does the addition of waist circumference and metabolomics to routine clinical measurements improve the estimation of visceral adipose tissue?
Estimating visceral adipose tissue using routine clinical measurements can be substantially improved by incorporating waist circumference, but not by adding metabolite measurements.
A 2022 study conducted an observational in Visceral adipose tissue estimation (n=4,772). Waist circumference and anthropometric measurements vs. Routinely measured variables alone was evaluated on Prediction model performance for visceral adipose tissue (R2 and RMSE). Adding waist circumference to routine clinical measurements improved the estimation of visceral adipose tissue (R2 increased from 0.50 to 0.58), whereas adding metabolite measurements did not.
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