Key result
The frequency of Treg cells and CD4+IL-9+ cells was significantly lower in the pleural fluid of patients with tuberculous pleural effusion compared to those with non-tuberculous pleural effusions.
Why the study?
Does the frequency of T helper cell subsets in pleural fluid differentiate tuberculous pleural effusions from non-tuberculous pleural effusions?
Population
88 HIV-negative patients with exudate pleural effusions, aged 18-84 years.
Comparison
Measurement of T helper cell subsets and… vs Non-tuberculous pleural effusions (MPE, EMP, PPE).
Design
Cohort
Authors
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Th subtype profiling in pleural fluid may differentiate TPE from MPE; leaves open diagnostic utility pending larger validation studies.
Observational (n=88)
No
Does the frequency of T helper cell subsets in pleural fluid differentiate tuberculous pleural effusions from non-tuberculous pleural effusions?
Absolute Event Rate: 4.2% vs 26.3%
p-value: p=<0.0001
Pleural fluid Treg cells and CD4+IL-9+ cells are significantly lower in tuberculous pleural effusions compared to non-tuberculous effusions, offering potential diagnostic utility alongside ADA.
Roofchayee et al. (2021) conducted an observational in Pleural effusion (n=88). Tuberculous pleural effusion vs. Non-tuberculous pleural effusion was evaluated on Frequency of Treg cells (CD4+CD25+FOXP3+) in pleural fluid (p=<0.0001). The frequency of Treg cells and CD4+IL-9+ cells was significantly lower in the pleural fluid of patients with tuberculous pleural effusion compared to those with non-tuberculous pleural effusions.