Key result
In patients with HTG-NAFLD, female gender, higher baseline transaminases, and higher fat mass percentage were significantly associated with a >30% decrease in ALT following 6 months of pemafibrate treatment.
Why the study?
What are the clinical predictors of responsiveness to pemafibrate treatment in patients with hypertriglyceridemia accompanying non-alcoholic fatty liver disease?
Case-Control (n=88)
Yes
What are the clinical predictors of responsiveness to pemafibrate treatment in patients with hypertriglyceridemia accompanying non-alcoholic fatty liver disease?
Pemafibrate effectively reduces liver enzymes and lipids in HTG-NAFLD, with female patients and those with higher baseline transaminases and fat mass showing the greatest responsiveness.
Answers are grounded in this paper and cite their sources.
Female sex, higher transaminases, and fat mass % may predict PEM response in HTG-NAFLD; leaves open need for prospective validation.
Aim: Pemafibrate (PEM) is a novel selective peroxisome proliferator-activated receptor alpha modulator that is effective for hypertriglyceridemia accompanying non-alcoholic fatty liver disease (HTG-NAFLD). This study aimed to identify the predictors of PEM efficacy for HTG-NAFLD in clinical practice. Methods: We retrospectively enrolled 88 HTG-NAFLD patients treated with PEM for 6 months for the analysis of routine blood and body composition testing. A PEM response was defined as a decrease in serum alanine aminotransferase (ALT) of >30% compared with pre-treatment level. The clinical features related to PEM responsiveness were statistically tested between responders and non-responders. Results: All 88 patients completed the 6 month drug regimen without any adverse effects. PEM treatment significantly decreased liver enzymes, triglycerides, and total cholesterol levels, without any detectable impact on body weight or body composition. Comparisons of baseline clinical features revealed female and greater aspartate aminotransferase (AST), ALT, and fat mass % levels to be significantly associated with a PEM response. The optimal cut-off values to predict responders as determined by receiver operating characteristic analysis were AST 45 U/L, ALT 60 U/L, and fat mass 37%. Conclusions: Female HTG-NAFLD patients with higher transaminase and fat mass % levels may be preferentially indicated for PEM treatment. Additional large-scale prospective studies are warranted to verify our results.
No takes yet. Share an insight, caveat, or question.
Iwadare et al. (2022) conducted a case-control in Hypertriglyceridemia accompanying non-alcoholic fatty liver disease (HTG-NAFLD) (n=88). Pemafibrate vs. Non-responders was evaluated on PEM response (>30% decrease in serum ALT). In patients with HTG-NAFLD, female gender, higher baseline transaminases, and higher fat mass percentage were significantly associated with a >30% decrease in ALT following 6 months of pemafibrate treatment.
Synapse has enriched 10 related papers. Consider them for comparative context: