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October 16, 2000The Journal of Experimental MedicineOpen Access

Bone Marrow–Derived Antigen-Presenting Cells Are Required for the Generation of Cytotoxic T Lymphocyte Responses to Viruses and Use Transporter Associated with Antigen Presentation (Tap)-Dependent and -Independent Pathways of Antigen Presentation

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Authors

LSLuis J. SigalThomas Jefferson UniversityKRKenneth L. RockBoston University

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Sigal et al. (2000) studied this question.

synapsesocial.com/papers/6ab326bfa2fc0c2a4f8943bahttps://doi.org/10.1084/jem.192.8.1143
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Roles of proteasomes, transporter for antigen presentation (TAP), and β 2-microglobulin in the processing of bacterial or particulate antigens via an alternate class I MHC processing pathway1996 · 162 citations
  2. 2Molecular analyses of a five-amino-acid cytotoxic T-lymphocyte (CTL) epitope: an immunodominant region which induces nonreciprocal CTL cross-reactivity1989 · 138 citations
  3. 3T cell specificity in twice-irradiated F1→parent bone marrow chimeras: failure to detect a role for immigrant marrow-derived cells in imprinting intrathymic H-2 restriction.1986 · 47 citations
  4. 4In Vivo Cross-Priming of MHC Class I–Restricted Antigens Requires the TAP Transporter1996 · 225 citations