Key result
Bare-metal stenting carries a ~31% 1-year cardiovascular event rate in obese men with CAD.
Why the study?
Predictors of cardiovascular events after coronary artery stenting in patients with obesity and coronary heart disease were not well defined.
What are the predictors of cardiovascular events in obese patients with CAD undergoing PCI with bare-metal stenting?
Cohort (n=186)
No
What are the predictors of cardiovascular events in obese patients with CAD undergoing PCI with bare-metal stenting?
Metabolic and inflammatory markers, along with epicardial fat thickness, predict cardiovascular events in obese patients undergoing PCI with bare-metal stents.
These markers may aid risk stratification in obese CAD men post-stenting; leaves open whether targeting them improves outcomes.
Aim. Study predictors of development of cardiovascular events after stenting of coronary arteries at patients with the coronary heart disease (CHD) with obesity.Material and methods. The study population included 186 (54,4±9,1 years) patients with coronary artery disease (CAD) and obesity undergoing percutaneous coronary intervention (PCI) with bare-metal stenting and at least 12 months of follow. The all patients research main and additional metabolic risk factors and epicardial fat thickness (EFT) with determination of echocardiography. Cardiovascular events were registered at 58 (31%) patients. The lipoprotein a - LP(а), leptin, blood glucose, interlaken-6, diastolic arterial pressure and index prevalence of coronary atherosclerosis on Gensini scale became predictors of cardiovascular events. The indicator of EFT showed interrelation with risk of a cardiovascular events. Conclusion. Determination of additional parameters of a lipid profile, carbohydrate metabolism, pro-inflammatory activity of plasma, neurohumoral activity of visceral fat and degree of epicardial adiposity is necessary for the purpose of formation of group of high risk of complications and carrying out prevention of risk factors before carrying out a coronary revascularization.
No takes yet. Share an insight, caveat, or question.
Veselovskaya et al. (2014) conducted a cohort in Coronary artery disease with obesity (n=186). Metabolic and inflammatory risk factors vs. Patients without cardiovascular events was evaluated on Cardiovascular events (acute coronary syndrome, repeat revascularization, restenosis, new stenosis, or cardiovascular death). In men with coronary artery disease and obesity, cardiovascular events occurred in 31.3% of patients within 1 year after bare-metal stenting, with lipoprotein(a), leptin, glucose, interleukin-6, and diastolic blood pressure identified as significant predictors.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: