A new, convenient and selective source of hydroxymethyl (•CH2OH) radical has been developed by persulfate oxidation of ethylene glycol with AgNO3 catalysis. The •CH2OH radical is selectively trapped by protonated heteroaromatic bases, providing a new, general process of hydroxymethylation; the importance of the β-scission of the alkoxyl radical intermediate is emphasised.
No takes yet. Share an insight, caveat, or question.
Minisci et al. (2004) studied this question.