Key result
Porcine parvovirus strain PPV2010 exhibits mixed genomic characteristics of virulent and vaccine strains, indicating its potential as a naturally attenuated candidate vaccine.
The complete genome sequence of Chinese PPV isolate PPV2010 reveals mixed virulent and vaccine strain characteristics, suggesting its potential utility as a naturally attenuated vaccine.
Supports evaluation of PPV2010 as a vaccine candidate in swine; leaves open confirmation of attenuation and field efficacy.
Porcine parvovirus (PPV) isolate PPV2010 has recently emerged in China. Herein, we analyze the complete genome sequence of PPV2010. Our results indicate that the genome of PPV2010 bears mixed characteristics of virulent PPV and vaccine strains. Importantly, PPV2010 has the potential to be a naturally attenuated candidate vaccine strain.
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Cui et al. (2012) studied this question. Porcine parvovirus strain PPV2010 exhibits mixed genomic characteristics of virulent and vaccine strains, indicating its potential as a naturally attenuated candidate vaccine.
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