Glucagon-like peptides, GLP-1 and GLP-2, show high conservation in different species and substantial sequence homology of glucagon.GLP-1 and GLP-2 have no effect on glycogenolysis, at least in part, directly in hepatocytes, in contrast to glucagon which caused marked stimulation of cAMP formation, glycogen phosphorylase a activity and glucose release in cultured rat hepatocytes.Furthermore, rat liver membranes do not exhibit specific binding of radiolabeled GLP-1, while GLP-1 has its own receptors in rat pituitary membranes.The presence of specific, high-affinity receptors for GLP-1 was confirmed by demonstrating that GLP-1 stimulated cAMP formation in the pituitary gland.These findings suggest that GLP-1 may not act on liver but act on brain and play a role in the central nervous system.
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Shimizu et al. (1986) studied this question.