Key result
Diabetes, CKD, and cerebrovascular disease linked to increased COVID-19 mortality in hypertensive patients.
Why the study?
Assessment of cardiovascular risk factors, associated clinical conditions, and target organ damage in patients with arterial hypertension depending on new coronavirus infection was needed.
What are the risk factors and clinical conditions associated with severe COVID-19 and mortality in patients with arterial hypertension?
Cohort (n=284)
What are the risk factors and clinical conditions associated with severe COVID-19 and mortality in patients with arterial hypertension?
p-value: p=<0.05
In patients with hypertension, comorbidities such as diabetes, chronic kidney disease, and cerebrovascular disease, as well as hyperuricemia and hypercholesterolemia, are associated with severe COVID-19 and increased mortality.
These comorbidities may guide risk stratification in hypertensive COVID-19 patients; extends associations but leaves causal inference and interventions open.
The purpose. Assessment of the presence of the cardiovascular risk factors, associated clinical conditions, the degree of target organ damage in patients with arterial hypertension depending on the new coronavirus infection. Material and methods. In a retrospective cohort study 284 patients with arterial hypertension were identified, 162 of them had a novel coronavirus infection and 122 patients didn’t have a history of a new coronavirus infection. Patients who had a new coronavirus infection were divided into groups depending on the disease. Inclusion criteria were the presence of arterial hypertension in history and taking antihypertensive therapy. Results. Patients with hypertension who’ve had a new coronavirus infection are more likely to have risk factors such as smoking, overweight, early menopause as opposed to patients with hypertension without indication of past COVID-19. Comparing patients with increased severity of the novel coronavirus infection elevated uric acid levels and hypercholesterolemia were associated with more severe COVID-19 (p < 0.05). Patients with chronic kidney disease, cerebrovascular disease, detection of atherosclerotic lesions of the brachiocephalic arteries and diabetes mellitus have an increased probability of deaths occur from the novel coronavirus infection (p < 0.05). There was no significant difference between the compared groups of coronary heart disease, atrial fibrillation, chronic heart failure and also the daily blood pressure profile and a severe course of COVID-19. Сonclusion. The presence of diabetes mellitus, cerebrovascular disease, chronic kidney disease, detection of atherosclerotic lesions of the brachiocephalic arteries, and also hyperuricemia or hypercholesterolemia in patients with hypertension revealed a risk of severe coronavirus infection.
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Solnceva et al. (2022) conducted a cohort in Arterial hypertension and COVID-19 (n=284). Novel coronavirus infection (COVID-19) vs. No history of novel coronavirus infection was evaluated on Severity of COVID-19 and probability of death (p=<0.05). In hypertensive patients, comorbidities including diabetes, chronic kidney disease, and cerebrovascular disease were associated with an increased probability of death from COVID-19 (p<0.05).
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