Key result
Abstinent male heroin-dependent subjects had increased relative beta-2 power and increased left intrahemispheric gamma coherence compared with healthy controls.
Why the study?
Do abstinent male heroin-dependent patients have altered EEG power and coherence measures compared to healthy controls?
Case-Control (n=30)
Do abstinent male heroin-dependent patients have altered EEG power and coherence measures compared to healthy controls?
Abstinent male heroin-dependent patients exhibit EEG abnormalities, including increased relative beta-2 power and left intrahemispheric gamma coherence, which may reflect underlying brain function changes due to long-term drug abuse.
This is the authors' abstract. We don't add key points for this paper.
Previous studies have shown that drug abuse is associated with altered brain function. However, studies of heroin abuse-related brain dysfunctions are scarce. Electroencephalographic (EEG) power and coherence analyses are two important tools for examining the effects of drugs on brain function. In the present study, we compared EEG power and coherence measures of 18 abstinent heroin-dependent subjects with those of 12 healthy control subjects. Furthermore, within the heroin group, associations between heroin use in the past, heroin craving and these EEG measures were studied. The results show that heroin-dependent subjects have increased relative beta-2 power and increased left intrahemispheric gamma coherence compared with control subjects. Furthermore, coherence measures showed correlations with clinical variables. These EEG abnormalities may reflect underlying changes in brain function due to long-term drug abuse and premorbid characteristics.
EEG changes may persist in abstinent heroin-dependent men; hypothesis-generating for neurophysiological biomarkers, should not yet change practice.
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Franken et al. (2004) conducted a case-control in Abstinent heroin dependence (n=30). Heroin dependence vs. Healthy control subjects was evaluated on EEG power and coherence measures. Abstinent male heroin-dependent subjects had increased relative beta-2 power and increased left intrahemispheric gamma coherence compared with healthy controls.
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