Key result
Platelet heparin-neutralizing fraction reverses heparin-induced thrombin and thromboplastin inhibition without intrinsic clot activity.
Why the study?
Lyophilized human platelet material contains distinct factors that generate thromboplastin and antagonize heparin, but their differentiation and properties were unclear.
This basic science study demonstrates that human platelets contain a specific aqueous fraction capable of antagonizing heparin's effects on thrombin and thromboplastin formation.
Answers are grounded in this paper and cite their sources.
Provides experimental basis for platelet heparin antagonism; leaves open clinical relevance and therapeutic targeting.
SummaryLyophilized human platelet material can be separated into thromboplastin-generating and heparin-antagonizing fractions. The heparin-antagonizing fraction does not, in itself, possess any thromboplastic activity but it reverses the effects of heparin on thromboplastin formation and thrombin activity. The material responsible is present in an aqueous extract of lipid-extracted platelets.
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Garrett et al. (1957) studied this question. The heparin-antagonizing fraction of human platelets reverses heparin's effects on thromboplastin formation and thrombin activity without possessing intrinsic thromboplastic activity.
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