Why the study?
Do heparin and its fractions induce platelet aggregation in human platelets?
Do heparin and its fractions induce platelet aggregation in human platelets?
Heparin induces concentration-dependent platelet aggregation partially through thromboxane production, an effect that is not always completely neutralized by protamine.
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Does not support changes in clinical heparin use; leaves open translation of thromboxane-mediated aggregation to human platelets in vivo.
Brace et al. (1985) studied this question.
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