Why the study?
Does high-dose heparin inhibit platelet accumulation in vivo?
Does high-dose heparin inhibit platelet accumulation in vivo?
High doses of heparin inhibit platelet accumulation induced by ADP, collagen, or PAF-acether in vivo, though the mechanism remains unclear and clinical relevance requires further study.
No takes yet. Share an insight, caveat, or question.
High-dose heparin antiplatelet effects remain preclinical; leaves open human translation and does not alter current practice.
Barrett et al. (1984) studied this question.