Why the study?
Does in vitro heparin exposure affect platelet count and aggregation in patients previously exposed to heparin compared to controls?
Population
64 subjects, comprising 26 recently treated with heparin, 18 on maintenance hemodialysis, and 20 normal…
Comparison
Blood collection in heparinized tubes vs Blood collection in EDTA tubes
Design
Cross-sectional
Authors
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Prior heparin exposure was associated with in vitro platelet changes; hypothesis-generating for proaggregatory antibodies and should not yet alter practice.
Does in vitro heparin exposure affect platelet count and aggregation in patients previously exposed to heparin compared to controls?
Prior exposure to heparin is associated with increased in vitro platelet aggregation and lower platelet counts when blood is re-exposed to heparin, suggesting the development of a proaggregator or antibody.
Shojania et al. (1987) studied this question.
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