Key result
Structural changes and mechanochemical cycles of kinesin and myosin motor proteins explain force transduction, ATP hydrolysis, and responses to small-molecule inhibitors and activators.
Understanding the mechanochemical coupling and energy transduction of kinesin and myosin motors provides insights into their function and highlights potential therapeutic targets for human diseases.
No takes yet. Share an insight, caveat, or question.
Hypothesis-generating for myosin mechanics in contraction; leaves open validation before cardiac research or practice implications.
Kull et al. (2012) reported a review. Structural changes and mechanochemical cycles of kinesin and myosin motor proteins explain force transduction, ATP hydrolysis, and responses to small-molecule inhibitors and activators.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: