Key result
Intracerebroventricular injection of beta amyloid peptide (1-42) significantly increased caspase-3 activity and lipid peroxidation in aged rats compared to young adult rats.
Why the study?
Does intracerebroventricular injection of beta amyloid peptide (1-42) increase caspase-3 activity and alter oxidative stress markers in young adult and aged rat brains?
Population
Young adult and aged rats
Comparison
Intracerebroventricular administration of beta… vs Control groups (young adult control, aged control)
Design
Preclinical
Authors
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Aβ heightens hippocampal caspase-3 activity and lipid peroxidation more in aged rats; leaves open therapeutic relevance of NOS changes in AD models.
Does intracerebroventricular injection of beta amyloid peptide (1-42) increase caspase-3 activity and alter oxidative stress markers in young adult and aged rat brains?
Intracerebroventricular injection of Aβ (1-42) increases caspase-3 activity and lipid peroxidation, particularly in the hippocampus of aged rats, supporting its use as an Alzheimer's disease model.
Çeti̇n et al. (2012) studied Alzheimer disease model. Intracerebroventricular injection of beta amyloid peptide (1-42) vs. Control (young adult and aged control groups) was evaluated on Caspase-3 activity, lipid peroxidation, nNOS and iNOS expression, MDA, GSH, and NOx. Intracerebroventricular injection of beta amyloid peptide (1-42) significantly increased caspase-3 activity and lipid peroxidation in aged rats compared to young adult rats.
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