Key result
A rare case of primitive neuroectodermal tumor of the gallbladder was diagnosed in a 53-year-old woman based on characteristic morphology and immunohistochemical findings.
Case Report (n=1)
This is the first reported case of a primitive neuroectodermal tumor (PNET) occurring in the gallbladder.
First reported gallbladder PNET expands known sites; leaves open its inclusion in the biliary small round cell differential pending larger series.
Ewing sarcoma/primitive neuroectodermal tumor (ES/ PNET) most commonly occurs in the soft tissues of the extremities and the paravertebral areas. To our knowledge, no case of PNET has been reported in the gallbladder to date. We report a case of PNET of the gallbladder occurring in a 53-year-old woman. Microscopically, the monotonous small round cells with a formation of Homer-Wright rosettes showed intense membranous positive immunoreactivity for MIC2/CD99, as well as for neuron-specific enolase and synaptophysin. Other small round cell tumors, such as lymphoma, rhabdomyosarcoma, or melanoma, were excluded in light of negative immunoreactivity for leukocyte common antigen, desmin, and S100. The diagnosis of PNET was rendered based on the characteristic morphology and immunohistochemical findings, despite an absence of chromosomal translocations, such as t(11; 22)(q24;q12) and t(21;22)(q22;q12).
No takes yet. Share an insight, caveat, or question.
Song et al. (2004) conducted a case report in Primitive neuroectodermal tumor (PNET) of the gallbladder (n=1). A rare case of primitive neuroectodermal tumor of the gallbladder was diagnosed in a 53-year-old woman based on characteristic morphology and immunohistochemical findings.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: