Key result
In three cases of peripheral primitive neuroectodermal tumor, multimodality treatment resulted in two patients surviving at 1.75 and 2 years, while one patient died 5 months after initial symptoms.
Case Report (n=3)
Radiological findings of peripheral PNET are not specific, but imaging is crucial for assessing tumor size, invasion, and response to therapy.
May support multimodality therapy in peripheral PNET; leaves open optimal regimens and prospective validation.
The authors describe three cases of peripheral primitive neuroectodermal tumor. The tumor was found in soft tissues of the crus, shoulder girdle and perineum, and was also located paravertebrally and epidurally at the level of L1-L2 vertebrae. Radiological findings were not specific for this disease. The results of imaging methods (sonography, CT, MRI, DSA) were important for the assessment of tumor size, its boundary and invasion of the surrounding tissues, and for the evaluation of tumor response to therapy and detection of recurrent disease. The PNET diagnosis was based on immunohistochemical, biochemical and cytogenetic examinations. One patient died 5 months after the first clinical signs were manifested; the two patients surviving for 2 and 1 3/4 years after first sign manifestation, respectively, remained in the care of cancer specialists.
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Koudelová et al. (2006) conducted a case report in Peripheral primitive neuroectodermal tumor (PNET) (n=3). Multimodality treatment (surgery, chemotherapy, radiotherapy) was evaluated on Survival. In three cases of peripheral primitive neuroectodermal tumor, multimodality treatment resulted in two patients surviving at 1.75 and 2 years, while one patient died 5 months after initial symptoms.
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