Key result
High hepatic fat content in obese adolescents was associated with significantly decreased expression of adiponectin and PPARγ2 in subcutaneous adipose tissue.
Population
26 obese adolescents, divided into low and high hepatic fat fraction groups based on HFF >5.5% measured by…
Design
Cross-sectional
Authors
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Associates hepatic fat with adipose dysfunction in obese youth; hypothesis-generating for insulin resistance mechanisms, no practice change yet.
Observational (n=26)
Reduced expression of adiponectin and PPARγ2 in abdominal subcutaneous adipose tissue is associated with high liver fat content and insulin resistance in obese adolescents, independent of overall obesity.
Kursawe et al. (2010) conducted an observational in Obesity and hepatic steatosis (n=26). High hepatic fat content (HFF > 5.5%) vs. Low hepatic fat content was evaluated on Adiponectin, PPARγ2, TNFα, and leptin gene expression in subcutaneous adipose tissue. High hepatic fat content in obese adolescents was associated with significantly decreased expression of adiponectin and PPARγ2 in subcutaneous adipose tissue.
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