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An intermolecular, quaternary carbon center forming [4+3] cycloaddition reaction catalyzed by Lewis base and Brønsted base has been successfully developed. The dual catalysis exhibits a superior ability to enable a previously challenging reaction, and the corresponding quaternary aza-spirocycloheptane oxindole scaffolds are efficiently synthesized with moderate to high yields.
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Xu et al. (2016) studied this question.
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