Key result
Serum copeptin is ~2-fold higher in adolescents with T1D and correlates with aortic IMT.
Why the study?
Copeptin was evaluated as an early marker of atherosclerosis in adolescent type 1 diabetic patients.
Does serum copeptin correlate with early markers of atherosclerosis (cIMT and aIMT) in adolescent type 1 diabetic patients?
Cross-Sectional (n=112)
No
Does serum copeptin correlate with early markers of atherosclerosis (cIMT and aIMT) in adolescent type 1 diabetic patients?
Absolute Event Rate: 9.43% vs 4.38%
p-value: p=0.0001
Serum copeptin is highly specific and sensitive for detecting early atherosclerosis (measured by aIMT and cIMT) in adolescent type 1 diabetic patients.
May indicate early atherosclerosis risk in adolescent T1D; hypothesis-generating and should not yet change practice.
AIM: To evaluate copeptin as an early marker of atherosclerosis in adolescent type 1 diabetics. METHODS: Sixty-two type 1 diabetic patients and 50 healthy volunteers were enrolled in the study. Serum copeptin, glycosylated haemoglobin (HbA1c), lipid profile, oxidised low-density lipoprotein (OxLDL), urinary albumin/creatinine ratio, carotid intimal medial thickness (cIMT), aortic intimal medial thickness (aIMT) and resistivity index were assessed for all participants in the study. RESULTS: HbA1c, albumin/creatinine ratio, lipid profile, OxlDL, copeptin, cIMT and aIMT were significantly higher in diabetic patients. Copeptin was higher in patients with positive cIMT and aIMT. Copeptin correlated with cIMT and aIMT. Stepwise multiple regression analysis found that copeptin correlated with aIMT. ROC curve showed that copeptin had 100 % specificity with aIMT and cIMT and 95.2 and 60,7 sensitivity with aIMT and cIMT respectively. CONCLUSION: Copeptin can be used as a marker for early detection of atherosclerosis of type 1 diabetic patients.
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Dayem et al. (2019) conducted a cross-sectional in Type 1 Diabetes (n=112). Type 1 diabetes vs. Healthy controls was evaluated on Serum copeptin levels (pg/ml) (p=0.0001). Serum copeptin levels were significantly elevated in adolescents with type 1 diabetes compared to healthy controls (9.43 vs 4.38 pg/ml) and strongly correlated with aortic intimal medial thickness.
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