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A model for the Trypanosomatid editosome is proposed, featuring a catalysis domain with separate sectors for insertion and deletion editing, and domains for anchor duplex and upstream RNA binding.
Proposes a structural and functional model for the multiprotein editosome responsible for RNA editing in Trypanosomatids.
Proposed editosome model organizes catalysis and RNA-binding domains; leaves open experimental validation for therapeutic targeting in trypanosomatid disease.
RNA editing in Trypanosomatids creates functional mitochondrial mRNAs by extensive uridylate (U) insertion and deletion as specified by small guide RNAs (gRNAs). Editing is catalysed by the multiprotein editosome. Over 20 of its protein components have been identified and additional proteins are likely to function in editing and its regulation. The functions of only a few editosome proteins have been determined. Surprisingly, there are related pairs or sets of editosome proteins, and insertion and deletion editing appear to be functionally and perhaps spatially separate. A model for the editosome is proposed, which has a catalysis domain with separate sectors for insertion and deletion editing. It also contains domains for anchor duplex and upstream RNA binding, which position the sequence to be edited in the catalysis domain.
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Stuart et al. (2002) conducted a review in Trypanosomatid RNA editing. A model for the Trypanosomatid editosome is proposed, featuring a catalysis domain with separate sectors for insertion and deletion editing, and domains for anchor duplex and upstream RNA binding.
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