Key result
Alfaxalone protocol preserves cardiovascular function during anesthesia in dogs with valvular disease.
Why the study?
Selecting appropriate anesthetic protocols and managing dogs with moderate to severe valvular degeneration during general soft tissue surgery requires guidance to preserve cardiovascular functions.
Is an anesthetic protocol of diazepam, alfaxalone, and 5 ml/kg/hr fluid rate safe for preserving cardiovascular function in dogs with stage C or D valve degeneration undergoing soft tissue surgery?
Case Report (n=3)
Is an anesthetic protocol of diazepam, alfaxalone, and 5 ml/kg/hr fluid rate safe for preserving cardiovascular function in dogs with stage C or D valve degeneration undergoing soft tissue surgery?
An anesthetic protocol using diazepam, alfaxalone, and controlled fluid rates appears safe for dogs with advanced degenerative valve disease undergoing soft tissue surgery.
May support this protocol in dogs with advanced valve disease; hypothesis-generating and should not yet change practice.
This case report aims to assist veterinarians in selecting appropriate anesthetic protocols and managing dogs with moderate to severe valvular degeneration during general soft tissue surgery.Three client-owned dogs with valve degeneration stages C or D who underwent general anesthesia for surgical treatment were included in this study.All dogs in this study were assigned to receive diazepam 0.3 mg/kg body weight, alfaxalone 2.5 mg/kg body weight, and a perioperative fluid rate of 5 ml/kg/hr.An appropriate assessment before and during surgery may help to prevent adverse events and preserve cardiovascular functions.This case report provides recommendations for anesthetic protocols and management in dogs with valvular heart disease.This study suggested that the anesthetic drug protocol of alfaxalone 2.5 mg/kg and a maintenance fluid rate of 5 mL/kg/hr in dogs with valve disease is safe and appropriate for preserving cardiovascular functions.
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Panprom et al. (2022) conducted a case report in Degenerative valve disease (n=3). Anesthetic protocol (diazepam, alfaxalone, perioperative fluid) was evaluated on Safety and preservation of cardiovascular functions. An anesthetic protocol of alfaxalone 2.5 mg/kg and a maintenance fluid rate of 5 mL/kg/hr was safe and appropriate for preserving cardiovascular functions in dogs with valve disease.
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