Development of pseudopeptides and peptidomimetics as eukaryote proteasome inhibitors

This is the authors' abstract. We don't add key points for this paper.

Deregulation of the ubiquitin–proteasome system has been implicated in the pathogenesis of many diseases. The regulation of the proteasome activity by specific inhibitors makes this enzyme a promising target for cancer treatment. We present here the design, synthesis and biological evaluation of novel pseudopeptides acting as inhibitors of eukaryote 20S proteasome. d -Amino acids were also introduced into the peptides of interest to reduce proteolysis.