Key result
SNP rs2229116 in the RYR3 gene was associated with common carotid intima-media thickness in HIV-infected white men after adjusting for age and stavudine use.
Why the study?
Is the RYR3 gene polymorphism associated with common carotid intima-media thickness in HIV-infected white men?
Observational (n=244)
Is the RYR3 gene polymorphism associated with common carotid intima-media thickness in HIV-infected white men?
Answers are grounded in this paper and cite their sources.
The RYR3 gene polymorphism rs2229116 is associated with increased cIMT, a surrogate marker for atherosclerosis, in HIV-infected white men.
To replicate the association of variants in RYR3 gene with common carotid intima-media thickness (cIMT), a surrogate marker of atherosclerosis, we genotyped single nucleotide polymorphisms (SNPs) rs2229116 and rs7177922 in a sub-population of 244 HIV-positive and HIV-negative men. SNP rs2229116 was associated with common cIMT in HIV infected white men after adjusting for age and use of stavudine (d4T). The association was more evident at younger ages and decreased among older individuals.
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Shrestha et al. (2012) conducted an observational in HIV infection (n=244). RYR3 gene variants (SNPs rs2229116 and rs7177922) was evaluated on Common carotid intima-media thickness (cIMT). SNP rs2229116 in the RYR3 gene was associated with common carotid intima-media thickness in HIV-infected white men after adjusting for age and stavudine use.
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