Key result
Chemotherapy and radiotherapy are linked to an early ~6% reduction in global longitudinal strain.
Why the study?
Chemotherapy and radiotherapy in cancer patients are associated with significant cardiotoxicity, and speckle-tracking echocardiography may help in early detection of these changes.
Does speckle-tracking echocardiography detect early cardiotoxicity in newly diagnosed cancer patients undergoing chemotherapy and/or radiotherapy?
Population
30 newly diagnosed cancer patients and 15 age- and gender-matched healthy controls
Comparison
Baseline vs after chemotherapy and/or thoracic radiotherapy
Design
Prospective observational study at a tertiary care center
Follow-up
After completion of cancer treatment
Authors
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May support speckle-tracking monitoring for early cardiotoxicity during cancer therapy; leaves open impact on outcomes and need for prospective trials.
Observational (n=45)
No
Does speckle-tracking echocardiography detect early cardiotoxicity in newly diagnosed cancer patients undergoing chemotherapy and/or radiotherapy?
Absolute Event Rate: -19.86% vs -21.16%
p-value: p=<0.01
Speckle-tracking echocardiography detects early subclinical left ventricular systolic dysfunction (reduced global longitudinal and circumferential strain) in cancer patients undergoing chemotherapy and/or radiotherapy before changes in LVEF are evident.
Jha et al. (2020) conducted an observational in Newly diagnosed malignancy (n=45). Chemotherapy and/or radiotherapy vs. Before cancer therapy was evaluated on Global longitudinal strain (p=<0.01). Chemotherapy and/or radiotherapy significantly reduced global longitudinal strain from -21.16 to -19.86 (P<0.01) in cancer patients, indicating early cardiotoxicity not detected by 2D echocardiography.
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