Key result
Genetic variants in lipoproteins and homocysteine may influence coronary heart disease risk.
Why the study?
Coronary heart disease is influenced by both environmental and genetic factors, and ongoing research explores the relationship between human genetic variation and disease to improve diagnosis and therapy.
This review highlights the potential role of genetic variations in lipid metabolism and homocysteine in affecting coronary heart disease risk.
Caution against routine genetic testing for CHD risk; leaves open targeted validation studies.
Coronary heart disease (CHD) is a complex disease that is affected by environmental as well as genetic factors. Research is ongoing that probes the relationship of human genetic variation to disease, potentially leading to better diagnosis and therapy. Variation in factors such as low-density lipoprotein cholesterol, apolipoprotein E, high-density lipoprotein cholesterol, apolipoprotein A-I/CIII/A-IV, lipoprotein lipase, cholesteryl ester transfer protein, lipoprotein (a), and homocysteine may affect CHD risk via genetic or environmental mechanisms or their interactions.
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Jan L. Breslow (2001) conducted a review in Coronary heart disease. Genetic markers was evaluated. Genetic variation in factors such as lipoproteins and homocysteine may affect coronary heart disease risk via genetic or environmental mechanisms.
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