The objective of the present study was to evaluate the in-vitro anti-cancer effects of ethanolic extract of seed of Myristica fragrans (Houtt) against seven human cancer cell lines ascribed to central nervous system, Colon cell (Colon502713,Colo205), Liver(Hep-2), Lung (A-549), Ovary OVCAR-5 and Prostrate (PC-5). The SRB assay was used to test cytotoxic activity for all the cell lines. The activity was evaluated at 100µg/ml concentration of test material. OVCAR-5 (Ovary) cell line showed highest cytotoxic activity (97%) Growth inhibition of colon 502713 and PC-5 (Prostrate) cell lines was 86%. SF-295(CNS) and Colo205 showed 73% growth inhibition, while Hep-2 (Liver) showed 72%. A-549 (Lung) showed no significant activity (50%). Our results indicate that the plant has a promising anti-cancer activity. The ethanolic extract of plant showed highest anti-cancer activity against OVCAR-5. Further investigation for active compound present in Myristica fragrans is required for cancer management and for the development of new anti- cancer drugs.
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Prakash et al. (2013) studied this question.
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