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Albuminuria followed by a decline in glomerular filtration rate has been described to be the classical phenotype of diabetic kidney disease (DKD).A new phenotype, non albuminuric diabetic kidney disease (NADKD), has recently been observed in patients with decreased renal function and a urine albumin excretion rate < 30 mg in 24 hours or a urine albumin creatinine ratio of < 30 mg/g.The prevalence of this phenotype is rising, and more studies are needed to understand its pathophysiological mechanisms.In this review, the pathophysiological mechanisms, clinical characteristics, and prognosis of NADKD compared to albuminuric DKD are discussed.
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Vinay Srinivasa (2022) studied this question.
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