Key result
Quinidine shows up to ~10-fold greater hypotensive potency than procainamide, with mixed cardiac effects.
Why the study?
The cardiovascular effects of quinidine and procainamide on intact dogs and isolated canine atria were not fully characterized.
What are the chronotropic, inotropic, and hypotensive effects of quinidine and procainamide in intact dogs and isolated canine atria?
Population
Intact donor dogs and isolated cross-perfused canine atria
Comparison
Quinidine versus procainamide effects
Design
Preclinical experimental study
Authors
Loading...
Alerts to dose-dependent hypotension with class Ia agents in dogs; leaves open human translation.
What are the chronotropic, inotropic, and hypotensive effects of quinidine and procainamide in intact dogs and isolated canine atria?
Quinidine and procainamide exhibit complex, dose-dependent cardiac-depressant and -stimulating properties in canine models, with quinidine showing greater hypotensive potency and a tendency to induce tachycardia.
Watanabe et al. (1982) studied this question. Quinidine and procainamide was evaluated on Cardiovascular effects including hypotension, chronotropism, and inotropism. Quinidine and procainamide produced dose-related hypotensive effects in dogs, with quinidine being 3-10 times more potent, and both drugs exhibited cardiac-depressant and -stimulating properties.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: