Key result
Disopyramide produced moderate contractions and potentiated the contractile response to norepinephrine in isolated dog arteries, indicating a nonspecific vasoconstricting action without alpha-adrenoceptor blocking properties.
Population
Isolated dog cerebral, coronary, and mesenteric arteries
Comparison
Disopyramide phosphate vs Procainamide and quinidine
Design
Preclinical
Authors
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Vascular effects may contribute to hemodynamic differences among class Ia agents; leaves open clinical relevance in humans.
The differing hemodynamic effects of antiarrhythmics like disopyramide, procainamide, and quinidine may be explained by their contrasting actions on arterial smooth muscle and alpha-adrenoceptors.
Toda et al. (1981) studied this question. Disopyramide vs. Procainamide and quinidine was evaluated on Contractile response of isolated dog arteries. Disopyramide produced moderate contractions and potentiated the contractile response to norepinephrine in isolated dog arteries, indicating a nonspecific vasoconstricting action without alpha-adrenoceptor blocking properties.
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