Why the study?
Does intravenous disopyramide compared with quinidine cause adverse hemodynamic effects in conscious dogs?
Does intravenous disopyramide compared with quinidine cause adverse hemodynamic effects in conscious dogs?
In conscious dogs, intravenous disopyramide exerts potent myocardial depressant and vasoconstrictor effects, unlike quinidine.
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Disopyramide's effects in dogs warrant hemodynamic caution in models; leaves open translation to human patients.
Walsh et al. (1979) studied this question.
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