January 12, 1979Acta Medica Scandinavica

Kinetics of Hemodynamic and Electrocardiographic Changes Following Intravenous Disopyramide

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Why the study?

Does intravenous disopyramide alter hemodynamic and electrocardiographic variables in patients with ventricular arrhythmias?

Population

9 patients with ventricular arrhythmias

Design

Case_series

Follow-up

at least 30 min

Authors

JHJohan HultingLinköping University GRG. RosenhamerKarolinska Institutet

Discussion

Member takes

Implication

May suppress ventricular ectopy acutely; leaves open net benefit given QT prolongation and negative inotropy.

Structured PICO

Does intravenous disopyramide alter hemodynamic and electrocardiographic variables in patients with ventricular arrhythmias?

Population

9 patients with ventricular arrhythmias

Intervention

Intravenous disopyramide (1.7 mg = 3.9 mmol/kg b.wt.)

Outcome

Changes in hemodynamic and ECG variables (QT and QRS intervals, systolic time intervals, aortic (dp/dt)max, diastolic pulmonary artery pressure) and number of ventricular ectopic beatssurrogate

Intravenous disopyramide effectively suppresses ventricular arrhythmias but is associated with significant QT/QRS prolongation and negative inotropic effects.

Cite This Study

Hulting et al. (1979) studied this question.

synapsesocial.com/papers/6a9996fdf2118addfb54c708 https://doi.org/10.1111/j.0954-6820.1979.tb06075.x

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Kinetics of Hemodynamic and Electrocardiographic Changes Following Intravenous Disopyramide

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Kinetics of Hemodynamic and Electrocardiographic Changes Following Intravenous Disopyramide

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider